(2020/02/19)Evidence of SARS-CoV-2 Infection in Returning Travelers from Wuhan, China +中文摘要轉譯

本研究探討無症狀感染者能否傳播SARS-CoV-2(導致Covid-19之病毒)。此次德國共撤離126名公民。所有旅客在離開中國前皆接受篩檢。在抵達法蘭克福後,有10名乘客直接後送法蘭克福大學醫院(2名接觸史、6名有症狀、2名家人疑似感染),經RT-PCR檢測皆呈陰性。餘116名乘客(5個月~68歲,23名兒童),有一名乘客於抵達後之健檢中,被認為有症狀,但RT-PCR檢測亦為陰性。餘115名無症狀旅客中,除一名旅客拒絕採檢外,其餘114名旅客皆接受採檢,有2名乘客證實感染SARS-CoV-2,並於Caco-2細胞培養中呈現感染力。研究指出,無症狀感染者,或僅輕微症狀感染者,亦有可能傳播具感染力之病毒。(國衛院莊淑鈞博士整理)

As the number of cases of infection with the novel coronavirus (SARS-CoV-2) has continued to increase, many countries have established restrictions regarding travelers who have recently visited China.1 With lockdown measures imposed in Hubei Province, China,2 and a public health emergency of international concern declared by the World Health Organization,3 foreign nationals have sought to return to their home countries from China, and public health authorities are racing to contain the spread of Covid-19 (the disease caused by SARS-CoV-2 infection) around the world. This process is complicated by epidemiologic uncertainty regarding possible transmission of the virus by asymptomatically or subclinically symptomatic infected persons. It is unclear whether persons who show no signs or symptoms of respiratory infection shed SARS-CoV-2.

In this context, a group of predominantly German nationals who had stayed in Hubei Province was evacuated to Frankfurt, Germany, on February 1, 2020. They were to be transferred to Germersheim, Germany, and quarantined for 14 days, since this period is thought to be the upper limit of the incubation period of SARS-CoV-2. Screening for symptoms and clinical signs of infection was performed before their departure from China. A total of 126 travelers were allowed to board an aircraft operated by the German air force (Figure 1).

Author: Sebastian Hoehl, Annemarie Berger, Marhild Kortenbusch,et al.

Link: https://www.nejm.org/doi/10.1056/NEJMc2001899