Importation and Human-to-Human Transmission of a Novel Coronavirus in Vietnam (2020/01/28)+中文摘要轉譯

1月28日新英格蘭臨床期刊報導指出, 越南一例武漢肺炎家族群聚感染, 父親為境外感染確診個案, 兒子則無出國史, 1月17日接觸其父親, 於1月20日開始有乾咳, 嘔吐, 軟便等症狀, 並於1月22日確診 推估2019-nCoV潛伏期可能3天或更短, 確診個案共接觸28位, 但均未有上呼吸道感染之症狀, 此境外感染武漢肺炎之家族群聚案例, 引起越南武漢肺炎”人傳人 情況之關注(國衛院蔡慧如博士整理)

The emergence and spread of a novel coronavirus (2019-nCoV) from Wuhan, China, has become a global health concern.1 Since the detection of the coronavirus in late December 2019, several countries have reported sporadic imported cases among travelers returning from China.2 We report one family cluster of 2019-nCoV originating from a Chinese man.

On January 22, 2020, a 65-year-old man with a history of hypertension, type 2 diabetes, coronary heart disease for which a stent had been implanted, and lung cancer was admitted to the emergency department of Cho Ray Hospital, the referral hospital in Ho Chi Minh City, for low-grade fever and fatigue. He had become ill with fever on January 17, a total of 4 days after he and his wife had flown to Hanoi from the Wuchang district in Wuhan, where outbreaks of 2019-nCoV were occurring. He reported that he had not been exposed to a “wet market”(a market where dead and live animals are sold) in Wuhan.

Figure 1.Radiographs of the Father’s Chest.

Throat swabs obtained from the patient tested positive for 2019-nCoV on real-time reverse-transcription–polymerase-chain-reaction (RT-PCR) assays.3 On admission to the hospital, the man was isolated and treated empirically with antiviral agents, broad-spectrum antibiotics, and supportive therapies. Chest radiographs obtained on admission showed an infiltrate in the upper lobe of the left lung (Figure 1A). On January 25, he received supplemental oxygen through a nasal cannula at a rate of 5 liters per minute because of increasing dyspnea with hypoxemia. The partial pressure of oxygen was 57.2 mm Hg while he was breathing ambient air, and a progressive infiltrate and consolidation were observed on chest radiographs (Figure 1B through 1D). His fever disappeared on January 25, and his clinical condition has improved since January 26. His wife had no symptoms of illness while they were traveling. She was healthy as of January 28.

Author: Lan T. Phan, Thuong V. Nguyen, Quang C. Luong, et al.

Link: https://www.nejm.org/doi/full/10.1056/NEJMc2001272?query=featured_home